Professional Agricultural Workers Journal

Article Title

Modulation of Colorectal Cancer by the Probiotic Organism Lactobacillus Reuteri

Authors

Camara A. Blasingame, Tuskegee UniversityFollow
Leonard H. Billups, Tuskegee University
Thomas Graham, Tuskegee University
JaNell Henry, University of North Carolina
Brianna Carter, Tuskegee University
David W. Threadgill, Texas A&M University
A. Deloris Alexander, Tuskegee UniversityFollow

Abstract

Abstract

Probiotics are beneficial to gastrointestinal health and have anti-inflammatory properties. An experiment was conducted to determine if L. reuteri could protect mice from azoxymethane-induced colorectal cancer (AOM-CRC). A/J mice were randomly assigned to controls, pre-treatment, or post-treatment groups. The mice in the groups were injected with 10mg/kg body weight of AOM and treated with L. reuteri; given only AOM; given only L. reuteri; or given neither AOM nor L. reuteri. At the end of a 26-week latency period, the mice were euthanized, dissected, and colons examined for tumors. L. reuteri did not protect animals against tumor formation. However, L. reuteri treatment had a significant effect on tumor number when the mice were segregated by gender (p = 0.014). There was no significant effect of regimen on tumor number (p = 0.667) or tumor size (p = 0.197). Ultimately, L. reuteri exhibited probiotic properties as a potential prophylactic treatment for colitis.

Recommended Citation

Blasingame, Camara A.; Billups, Leonard H.; Graham, Thomas; Henry, JaNell; Carter, Brianna; Threadgill, David W.; and Alexander, A. Deloris (2016) "Modulation of Colorectal Cancer by the Probiotic Organism Lactobacillus Reuteri," Professional Agricultural Workers Journal: Vol. 3: No. 2, 3.
Available at: https://tuspubs.tuskegee.edu/pawj/vol3/iss2/3